Calcium D-Glucarate 90 Capsules

Calcium D-Glucarate is ideal for supporting healthy oestrogen metabolism and liver detoxification. It works by enhancing the glucuronidation pathway, which helps the liver package and eliminate hormones and toxins. This is particularly beneficial for individuals with symptoms of oestrogen dominance or those looking to support hormonal balance, immune resilience, or toxin clearance.

By inhibiting beta-glucuronidase, it also prevents the reabsorption of toxins in the gut, making it a powerful dual-action supplement for hormone support and digestive health.

It is particularly helpful for anyone wishing to reduce their oestrogen levels, or who has a family history of issues associated with excess oestrogen.

Calcium D-Glucarate is a combination of glucaric acid bound to calcium. Glucaric acid is a naturally occurring chemical found in our bodies and in certain fruits and vegetables, albeit, in very small amounts.

Calcium D-Glucarate supports the glucuronidation pathway of detoxification. The glucuronidation pathway is one of the most important phase II conjugation pathways in the liver. The liver is the major detoxification organ of the body. Glucuronidation is a normal process that happens within the liver, where a glucuronic acid molecule is attached to certain substances that need to be detoxified and eliminated from the body. Toxic chemicals, steroid hormones and other fat-soluble toxins undergo glucuronidation during phase II detoxification of the liver, and they are then excreted either through bile (and into the intestines) or the urine.

This crucial process – the glucuronidation pathway - can be interrupted by high levels of beta-glucuronidase. The enzyme beta-glucuronidase, when produced by gut bacteria, can de-conjugate the glucuronide-toxin complex, freeing toxic substances in the gut, which may cause damage locally or be reabsorbed systemically. Toxins are most damaging in their free form, which is why we want them to be bound (conjugated) and then released from the body. Calcium D-Glucarate has been shown to inhibit the activity of beta-glucuronidase, helping to ensure this process can occur uninterrupted, allowing toxins to be removed.

DIM (diindolylmethane) is a compound found in cruciferous vegetables which supports phase I liver detoxification, while Calcium D-Glucarate works on phase II liver detoxification and elimination of certain substances through the bowels.

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Nutri Advanced is transitioning to the Metagenics brand to align more closely with our global family, who we joined in 2022. We have worked closely with Metagenics for decades with many of our products produced from their European Headquarters in Belgium. Metagenics is a global leader in the professional supplements market and is renowned for clinically proven, precision-crafted formulas to support your health. In 2024, they were voted the No. 1 Doctor Recommended Professional Supplement Brand in the US. They also held the No. 1 VMS position in Belgium for their Magnesium product, MetaRelax, and had the most prescribed probiotics brand among health professionals in Italy and Australia.

The change from Nutri Advanced to Metagenics will give you access to even more ground-breaking new product innovations and nutritional resources whilst maintaining our trusted formulations and excellent UK based customer service.